Release date: 2017-02-06 When you have just given birth to a child, the nurse will take the child a little blood and hand it to the lab for a series of tests. But in most cases you will hardly get any test results, because your child is usually lucky enough not to have rare diseases such as cystic fibrosis, sickle cell anemia. And as a parent, you may not even remember the newborn screening. Newborn screening is required in most states in the United States unless parents refuse or cannot be tested for religious or other factors. Parents usually receive screening for newborns because screening is only for a small number of major illnesses, and once diagnosed early, it is likely to eliminate the disease and even save the child's life. But now scientists have developed a genome-wide sequencing approach. What if the government starts using these methods to detect the health of newborns? How will this work? What information should parents get? What information should not be obtained? In order to solve these problems, the US NIH funded a team of researchers and doctors from multiple institutions (NSIGHT), which teamed up with newborn parents to conduct genetic sequencing of newborns, trying to find information to improve the use of this new technology. Guidelines to determine how to apply this technique more effectively to newborn screening or care, and their research was recently published in Pediatrics. “How to determine what information parents should know is important. They should know if their children are healthy, but they should not let them know too much to prevent them from interfering with their normal growth and development at the genetic level.†Associate Professor, University of North Carolina School of Medicine Jonathan Berg said he is the co-author of the study. “This is one of the most important bioethical issues of our time: at what level should we protect the rights of children to make their own decisions? Some people think that new technologies have made this concept obsolete, and some people think this will interfere with children’s autonomy. Right, even parents may hurt children." A very striking example is Huntington's disease. Some children carry genetic defects that may cause illness, but until adult children do not have symptoms, should parents know this? What about neurodegenerative diseases that develop in childhood? If early intervention may help, but what if the child may not become ill in adulthood? Regardless of what people think, Berg said: "Technology drives us to make decisions about these processes." The cost of genome sequencing has been reduced, which means that the national public health system and the medical community need to find solutions to these problems in the near future. Researchers and doctors in the NIH-funded NSIGHT team are doing some basic work, mainly in the following three areas: Diagnosis: Use genetic sequencing to identify specific pathogenic genes that may cause congenital malformations or genetic diseases in neonates into the ICU; Prevention: Use genetic sequencing to screen for preventable or treatable diseases that may occur in healthy newborns; Prediction: Whole-genome sequencing of newborns as initial data for life-long care. Currently, NISIGHT's doctors and researchers are consulting people who have or will become parents to find their concerns and opinions about genetic testing for a variety of purposes. “We are learning when it is the best time to get in touch with our parents,†Berg said. “It’s obvious that we can’t say to these just-in-laws when the child is born.†We want to talk to you about the sequencing of your child’s genome. Things. We are learning what information and resources parents need, such as genetic counseling. We are also considering how to conduct genetic counseling in the absence of genetic counselors in the US. We cannot allow every couple to sit down and communicate with genetic counselors. , but we may be able to ask them for online consultation." The Boston-based NSIGHT project is led by Dr. Robert Green, Department of Genetics, Brigham and Women's Hospital, Dr. Alan Beggs, Professor of the Manton Orphans Research Center at Boston Children's Hospital, and Harvard Medical School. They are co-authors of this article. “It’s just a grand project to bring these people and resources together to design this complex project, as we said in our article,†said Green, who is also at Harvard Medical School and the Bode Institute. Doctor and scientist. “But it’s important to find methods or standards that rigorously assess the clinical use of these new technologies so that we can answer these parents’ questions responsibly, which is the focus of all NSIGHT projects.†Beggs added, “Gene sequencing is a new technology, the process is very complex, and the results have some uncertainty. So these studies will help us determine how to properly use gene sequencing in the short term, which will help us determine how Give the right information to the child's parents and doctors in the right way." Berg explained that their team found that although many parents are not interested in their newborn gene sequencing, many parents want to know the child's genetic information. “Maybe the best way is to focus on doing our genetic counseling.†“At least this is the bottom line,†Berg added. “We hope that the information we get from these studies will help us determine how to better sequence the newborn genome in the future.†Source: Translational Medicine Network Lh Ovulation Strip,Lh Ovulation Cassette,Ovulation Rapid Test Strip,Diagnostic LH Ovulation Test Kits Weihai Kangzhou Biotechnology Engineering Co.,Ltd , https://www.weihaikangzhou.com